| Information Item | Value |
|---|---|
| Dataset Name | Yeast Genome Expression Responses to Environmental Changes |
| Dataset Number | 64 |
| Short Description | Expression Time Series following treatment with heat, acid, alkali, hydrogen peroxide, salt, sorbital, and during diauxic shift |
| Source URL | http://staffa.wi.mit.edu/young_public/environment/ |
| Reference | Causton, HC; Ren, B; Koh, SS; Harbison, CT; Kanin E; Jennings, EG; Lee, TI; True, HL; Lander, ES; Young, RA; Remodeling of Yeast Genome Expression in Response to Environmental Changes.; Mol Biol Cell 12:323-337 (2001) |
| Strains | S288C strain ATCC-201388 |
| Conditions | Grown on YPD |
| Date Added to ExpressDB | Sep 5 2002 11:41:41:353AM |
| Number of Measures on ExpressDB | 90 (here to download dataset and view measure details) |
| Long Description | Abstract from reference: We used genome-wide expression analysis to explore how gene expression in Saccharomyces cerevisiae is remodeled in response to various changes in extracellular environment, including changes in temperature, oxidation, nutrients, pH, and osmolarity. The results demonstrate that more than half of the genome is involved in various responses to environmental change and identify the global set of genes induced and repressed by each condition. These data implicate a substantial number of previously uncharacterized genes in these responses and reveal a signature common to environmental responses that involves ~10% of yeast genes. The results of expression analysis with MSN2/MSN4 mutants support the model that the Msn2/Msn4 activators induce the common response to environmental change. These results provide a global description of the transcriptional response to environmental change and extend our understanding of the role of activators in effecting this response. |
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Copyright (c) 2006 by Wayne Rindone and the President and Fellows of Harvard University