Center for Causal Transcriptional Consequences of Human Genetic Variation (CTCHGV)
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Professor George Church (Harvard
Medical School), CTCHGV’s proposed director, has several times developed
innovations that exhibited improvement factors of 10 or more in scale or
power compared to contemporaneous commercial collaborators. Indeed, Professor
Church led a prior Molecular Genomics and Imaging CEGS (MGIC) that
consistently developed improved sequencing methods ~2 years ahead of
commercial efforts which later adapted many of our innovations: Under him,
MGIC demonstrated his initial polymerase colony (polony) methods in 2003,
versions of which are now widely used commercially (Illumina, ABI), while in
2005 MGIC developed sequencing by ligation, which is now in use in ABI SOLiD. Another example is in DNA synthesis, where
he has led the way in synthesis and use of complex oligo mixtures cleaved
from arrays for large construct assembly and targeted sequencing, and where
in the course of four years he has advanced from 4000 90-mer to 54000 150-mer
oligo arrays. |
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Dr.
George Q. Daley’s (Harvard Medical School, Children’s
Hospital, HHMI) work has transformed the field of stem cell development and
differentiation. Recipient of numerous
awards, including the first NIH Director’s Pioneer Award, as well as major
awards from the American Philosophical Society, Society for Pediatric
Research, Burroughs Wellcome Fund, and the Leukemia and Lymphoma Society of
America, Dr. Daley’s work focuses on functional hematopoietic and germ cell
elements from ES cells, and the genetic mechanisms that predispose to
malignancy. Dr. Daley’s lab was one of the first three world-wide to derive
human iPS cells, and the first to produce a repository of patient-specific
iPS cells (from 10 different disease conditions). |
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Dr. J. Keith Joung (Harvard Medical
School, Massachusetts General Hospital) is a leading expert on the development
of zinc-finger nucleases for human cell engineering and gene targeting. He is
the leader and co-founder of the Zinc Finger Consortium (http://www.zincfingers.org/), which
was established to ensure and to promote continued research and development
of engineered zinc finger technology. The Consortium is committed to
developing a zinc finger engineering platform that is robust, user-friendly,
and freely available to the academic scientific community. |
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Professor Kun Zhang (UCSD) developed
innovative methods for long range haplotyping, single cell genome sequencing,
targeted sequencing, and measurement of allele-specific expression, as a
post-doc in the Church Lab, where he was a member of the MGIC team. He has also worked with Professor Church on
methods for targeted exon sequencing in connection with an NHLBI grant
(HLB08-004). |
Last modified: 10/18/2010 7:55 AM by John Aach