Our abiity to (epi)genetically reprogram cells from one tissue type (or age) to another is expanding rapidly. The rules are just becoming evident for accelerating or skipping developmental steps, establishing transcriptome and reporter assays, and selecting for factors in large libraries. Relevant Church Lab Publications:
2013 Discovery of a deterministic gene regulatory network driving rapid neuronal differentiation in human stem cells. Submitted.
2012 Reading and writing omes. MSB.
2009 A Robust Approach to Identifying Tissue-specific Gene Expression Regulatory Variants Using Personalized Human Induced Pluripotent Stem Cells. PLoS Genetics.