Emerging Field

Novel Polymer Encoding Methods

Team Method Goal In vivo
CatalogDNA -InfoN
Centrilliontech* Chem+EnzSeqN
DNAScript EnzBioN
Iridia* -InfoN
Evonetix* -BioN
Glotta Tech* TdTInfoN
Kalhor et al. 2017* Cas9InfoY
Microsoft* ChemInfoN
Molecular Assemblies TdTBio+InfoN
Nuclera* TdTBioN
Shipman et al. 2017* Cas1/2InfoY
Technicolor* ChemInfoN
Twist* ChemBio+InfoN

Chem: Phosphoramidite, water-free acetonitrile, etc.
Enz: Enzymatic Polymerization (PNP, TdT, ligase, etc.)
TdT: Terminal deoxynucleotidyl Transferase
Bio: High fidelity required for synthetic biological applications
Info: Storage Lower raw accuracy, yet high consensus accuracy
Seq: Oligos for complete genome sequencing
In vivo, Y: applications to recording biological data in living cells
* = Church lab related.
Molecular Information Storage -- MIST IARPA.