Publications on Safety, Policy, Ethical, Legal Social Implications (ELSI) from the Church lab

(A subset of Church lab publications and news items.)

26. Saha K, Hurlbut JB, Jasanoff S, Ahmed A, Appiah A, Bartholet E, Baylis F, Bennett G, Church G, Cohen IG, Daley G, Finneran K, Hurlbut W, Jaenisch R, Lwoff L, Kimes JP, Mills P, Moses J, Park BS, Parens E, Salzman R, Saxena A, Simmet H, Simoncelli T, Snead OC, Rajan KS, Truog RD, Williams P, Woopen C. Building Capacity for a Global Genome Editing Observatory: Institutional Design. Trends Biotechnol. PMID: 29891181

25. Hurlbut JB, Jasanoff S , Saha K, Ahmed A, Appiah A, Bartholet E, Baylis F, Bennett G, Church G, Cohen IG, Daley G, Finneran K, Hurlbut W, Jaenisch R, Lwoff L, Kimes JP, Mills P, Moses J, Park BS, Parens E, Salzman R, Saxena A, Simmet H, Simoncelli T, Snead OC, Rajan KS, Truog RD, Williams, P Woopen C (2018) Building Capacity for a Global Genome Editing Observatory: Conceptual Challenges. Trends in Biotechnology. PMID: 29871776

24. Farahany NA, Greely HT, Koroshetz W, Gordon JA, Hyman S, Koch C, Eberwine J, Grady C, Pașca SP, Arlotta P, Sestan N, Ramos K, Rommelfanger KS, Lunshof JE, Iyer EPR, Hyun I, Johnson LSM, Capestany BH, Church GM, Huang H, Bernat J, Ting J, Song H (2018) The ethics of experimenting with human brain tissue. Nature 556(7702):429-432. PMID: 29691509

23. Church GM (2017) Compelling Reasons for Repairing Human Germlines. NEJM 377:1909-1911. PMID: 29141159

22. Aach J, Lunshof J, Iyer E, Church GM (2017) Addressing the ethical issues raised by synthetic human entities with embryo-like features. ELife 6:e20674. PMID: 28494857

21. Boeke JD, Church G, Hessel A, Kelley NJ, Arkin A, Cai Y, Carlson R, Chakravarti A, Cornish VW, Holt L, Isaacs FJ, Kuiken T, Lajoie M, Lessor T, Lunshof J, Maurano MT, Mitchell LA, Rine J, Rosser S, Sanjana NE, Silver PA, Valle D, Wang H, Way JC, Yang L (2016) Science. The Genome Project-Writesupplementresources. PMID: 27256881

20. Church G. (2015) Perspective: Encourage the innovators. Nature. 528(7580):S7. PMID: 26630599

19. Esvelt K, Church G, Lunshof J (Jul 2014) Gene Drives and CRISPR Could Revolutionize Ecosystem Management. Scientific American.

18. Lunshof JE, Church GM, Prainsack B. (28-Feb-2014) Raw data: access to inaccuracy--response. Science 343(6174):969. PMID: 24578564

17. Ball MP, Bobe JR, Chou MF, Clegg T, Estep PW, Lunshof JE, Vandewege W, Zaranek AW, Church GM (2014) Harvard Personal Genome Project: Lessons from Participatory Public Research. Genome Medicine. PMID: 24713084

16. Lunshof JE, Church GM, Prainsack B (2013) Raw Personal Data: Providing Access and Agency. Science 343(6169):373-4. PMID: 24458627

15. Church GM (2013) Improving Genome Understanding Nature 502:143. PMID: 24108012

14. Church G. Please reanimate. (2013) Sci Am. 309(3):12. PMID: 24003542.

13. Church GM, Regis E (2012) Regenesis: How Synthetic Biology Will Reinvent Nature and Ourselves 288 pages. Basic Books, publisher.  (especially the epilogue).

12. Ball MP*, Thakuria JV*, Zaranek AW*, Clegg T, Rosenbaum AM, Wu X, Angrist M, Bhak J, Bobe J, Callow M, Cano C, Chou MF, Chung WK, Douglas SM, Estep P, Gore A, Hulick P, Labarga A, Lee J, Lunshof J, Kim BC, Kim JI, Li Z, Murray MF, Nilsen GB, Peters B, Raman AM, Reinhoff HY, Robasky K, Wheeler M, Vandewege W, Vorhaus D, Yang JL, Yang L, Aach J, Ashley EA, Drmanac R, Kim SJ, Li JB, Peshkin L, Seidman CE, Seo JS, Zhang K, Rehm HL, Church GM (2012) A Public Resource Facilitating Clinical Use of Genomes. Proc Natl Acad Sci USA. 109(30):11920-7 (inaugural article) PMID: 22797899

11. Church GM (2011) Thoughts on the Manchester Manifesto. Prometheus 29 (3):343-344.

10. Church G (2011) Non-Inherent Inheritance. Edge World Question (Jan 2011).

9. Lunshof JE, Bobe J, Aach J, Angrist M, Thakuria JV, Vorhaus DB, Hoehe HR, Church GM (2010) Personal genomes in progress: from the human genome project to the personal genome project. Dialogues Clin Neurosci. 2010;12(1):47-60. PMID: 20373666

8. Church GM (2009) Safeguarding BiologySeed 20:84-86.

7. Church GM (2008) Evolution of Faith In Experiments Edge World Question (Jan 2008).

6. Lunshof JE, Chadwick R, Church GM (2008) Hippocrates revisited? Old ideals and new realities. Genomic Med. 2(1-2):1-3. PMID 18716915

5. Lunshof JE, Chadwick R, Vorhaus DB, Church GM (2008) From genetic privacy to open consent. Nat Rev Genet. 2008 May;9(5):406-11. PMID: 18379574

4. Church GM (2006) Genomes for all . Scientific American Jan 2006. PMID: 16468433

3. Church GM (2004) A Synthetic Biohazard Non-proliferation Proposal.

2. Church GM (2005) Let us go forth and safely multiply. Nature 438: 423. PMID: 16306966

1. Church GM (2005) The Personal Genome Project. Nature EMBO Molecular Systems Biology doi:10.1038/msb4100040. PMID: 16729065


3. Lunshof J (2016) Human germ line editing—roles and responsibilities Protein Cell. PMID: 26511643

2.  Lunshof J (2016) World View: Regulate gene editing in wild animals. Nature 521:127.

1. Lunshof JE, Ball MP (2013) Our genomes today: time to be clear. Genome Medicine 5:52. PMID: 23806003


News, video and other media covering Safety, Policy, Ethical, Legal Social Implications (ELSI) from the Church lab

20. What Do We Mean by Human Enhancement? (NYAS, 15-May-2018 | Josephine Johnston)

19. The Promises and Perils of Gene Editing (HMS Talks@12, 17-Jan-2018, 60 min film | George Church)

18. CRISPR, Gene Drive Technology, and Hope for the Future (Future of Life, 16-May-2016 | John Min, George Church)

17. New chat with George Church on CRISPR’ing people, Zika, weapons, & more (IPSCell, 18-Apr-2016 | Paul Knoepfler)

16. Should Heritable Gene Editing Be Used on Humans? (The Wall Street Journal, 11-Apr-2016, See comments | George Church, Marcy Darnovsky)

15. The Frankenstein Problem: How to Talk About Genetic Engineering (NYU Journalism, 6-Apr-2016, 90 min video | Robert Lee Hotz, Amy Harmon, George Church)

14. The Augmented Human Being (Edge.org, 30-Mar-2016, 50 min video | John Brockman, George Church)

13. Eight questions to ask before human genetic engineering goes mainstream. (The Washington Post, 25-Feb-2016 | George Church)

12. Gene editing, plastic surgery and woolly mammoths: My 20 minutes with George Church (Boston Business Journal, 29-Jan-2016 | Don Seiffert)

11. Artificial Natures (Harvard Design Magazine, 22-Jun-2015 | Matthew Allen)

10. A debate: Should we edit the human germline? (Stat, 30-Nov-2015 | Patrick Skerrett, Francis Collins, George Church)

9. Synthetic biology legend George Church & I talk about science and civilization (TheFurtureofPrintedFiction, 1-Nov-2015, 80 min video | John Sundman)

8. Manipulating the Human Genome (CG Researcher, 19-Jun-2015 | Jill U Adams, Marcy Darnovsky , Jessica Cussins, George Church)

7. Genome Engineering 3.0: Safety (MIT Alumni Association,  9-May-2015 47 minute video | George Church)

6. Getting Personal with Genomics (Genentech, 23-Oct-2013 | George Church)

5. Lessons From The Neanderthal Baby That Wasn't (Forbes, 22-Jan-2013 | Matthew Herper)

4. Harvard professor blasts Neanderthal clone baby rumor on Web (Boston Herald, 22-Jan-2013 | Gary J. Remal)

3. Researcher Pumps Brakes on Notion of Cloning Neanderthals (US News, 25-Jan-2013 | Jason Koebler)

2. Expect Changes: Genetics in 20 Years (GeneWatch, 16-Feb-2012 | George Church)

1. The Genome Generation (Newsweek, 14-Dec-2009 | George Church)

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