Computational Discovery of Overlapping Transcriptional Units in the Human & Mouse Genomes

Candidate UniGene cluster:UniGene Cluster Hs.10882
Description:HMG-box containing protein 1
Best-Of-UniGene (BOU) SequenceNM_012257
Genomic Coordiantes Displayed:Bases 380000 to 520000 of contig Hs7_8071_24
BOU Orientation Along Contig:LEFT-TO-RIGHT with respect to contig
Link to JPEG of genomic mappingHs.10882.jpeg
Best sense EST/protein match:AI858295 matched ref|NP_036389.1| (NM_012257) HMG-box containing protein 1 [Homo sapiens] (E = e-108)
Best antisense EST/protein match:No protein match with an e-value of less than 1e-10

This page provides information on exon-intron structure, mouse-human homologies, polyA signals & locations, and protein homologies of ESTs from directionally-cloned libraries that are members of a UniGene cluster that is a candidate for containing ESTs derived from distinct, overlapping sense & antisense transcripts.
The upper portion of the graph is reserved for the exon-intron mappings of ESTs oriented consistently with the Best-Of-UniGene (BOU) sequence (in gold). The lower portion of the graph is reserved for the exon-intron mappings of ESTs oriented opposite the BOU sequence (in white). Dividing these portions are the exon-intron mapping of the BOU sequence itself (in blue and green). Immedietely below the BOU are HUMMUS-defined streches of sequences highly conserved between mouse and human. The height of each bar is reflective of the % identity of human-mouse homology over a 100 base-pair window centered at a given base. At the left of the graph, the GenBank accession number of the BOU or EST sequence represented along that Y-axis position is listed, along with the UniLib identification number of the library from which that EST was derived.Below the graph, the GenBank accession numbers of each of the sense & antisense ESTs are provided, along with information on which have polyA signals and protein homologies, as determined by the NCBI.

Below are listed the same set of ESTs as is depicted above, with information of read direction, tissue type, protein similarity (P), and poly-adenylation signal (A).

  AI434729 cDNA clone IMAGE:2132912 lymph 3' read 0.6 kbPolyadenylation signal
  AA553415 cDNA clone IMAGE:1019504 neural 3' read 4.2 kbProtein similarity
  R16053 cDNA clone IMAGE:53072 brain 3' read
  R41492 cDNA clone IMAGE:29380 brain 3' read 2.1 kb
  Z39236 cDNA clone c15a11 brain 3' read
  R16054 cDNA clone IMAGE:53072 brain 5' read Protein similarity
  R15058 cDNA clone IMAGE:29380 brain 5' read 2.1 kb
  Z43156 cDNA clone c15a11 brain
  BF672650 cDNA clone IMAGE:4293130 muscle (skeletal) 5' read
  AW274637 cDNA clone IMAGE:2747296 three pooled meningiomas 3' read Polyadenylation signal
  AU144340 cDNA clone HEMBA1001610 whole embryo, mainly head 3' read Polyadenylation signal
  AA365591 cDNA clone ATCC:170339 brain 3' read Polyadenylation signal
  BF966743 cDNA clone IMAGE:4375614 hippocampus, cell line 3' read
  AI862311 cDNA clone IMAGE:2265161 uterus 3' read 0.4 kb
  BG743270 cDNA clone IMAGE:4778629 skin 5' read
  BG168142 cDNA clone IMAGE:4449535 hypernephroma, cell line 5' read
  AW130049 cDNA clone IMAGE:2619269 uterus 3' read


  BG719537 cDNA clone IMAGE:4822437 testis, cell line 5' read Protein similarity
  AU098630 cDNA clone COL05935 Protein similarity
  BI459469 cDNA clone IMAGE:5266334 testis, cell line 5' read Protein similarity
  BG400241 cDNA clone IMAGE:4592743 kidney 5' read Protein similarity
  BG721926 cDNA clone IMAGE:4827901 testis, cell line 5' read Protein similarity
  BI668401 cDNA clone IMAGE:5311891 hypothalamus, cell line 5' read Protein similarity
  AU127771 cDNA clone NT2RP2002014 5' read Protein similarity
  BG426750 cDNA clone IMAGE:4606827 kidney 5' read Protein similarity
  BF575809 cDNA clone IMAGE:4289628 muscle (skeletal) 5' read Protein similarity
  AV718093 cDNA clone FHTAAAD11 hypothalamus 5' read Protein similarity