Computational Discovery of Overlapping Transcriptional Units in the Human & Mouse Genomes

Candidate UniGene cluster:UniGene Cluster Hs.170263
Description:tumor protein p53-binding protein, 1
Best-Of-UniGene (BOU) SequenceNM_005657
Genomic Coordiantes Displayed:Bases 5270000 to 5340000 of contig Hs15_10351_24
BOU Orientation Along Contig:RIGHT-TO-LEFT with respect to contig
Link to JPEG of genomic mappingHs.170263.jpeg
Best sense EST/protein match:BE272687 matched ref|NP_005648.1| (NM_005657) tumor protein p53 binding protein, 1; tumor protein (E = e-102)
Best antisense EST/protein match:No protein match with an e-value of less than 1e-10


This page provides information on exon-intron structure, mouse-human homologies, polyA signals & locations, and protein homologies of ESTs from directionally-cloned libraries that are members of a UniGene cluster that is a candidate for containing ESTs derived from distinct, overlapping sense & antisense transcripts.
The upper portion of the graph is reserved for the exon-intron mappings of ESTs oriented consistently with the Best-Of-UniGene (BOU) sequence (in gold). The lower portion of the graph is reserved for the exon-intron mappings of ESTs oriented opposite the BOU sequence (in white). Dividing these portions are the exon-intron mapping of the BOU sequence itself (in blue and green). Immedietely below the BOU are HUMMUS-defined streches of sequences highly conserved between mouse and human. The height of each bar is reflective of the % identity of human-mouse homology over a 100 base-pair window centered at a given base. At the left of the graph, the GenBank accession number of the BOU or EST sequence represented along that Y-axis position is listed, along with the UniLib identification number of the library from which that EST was derived.Below the graph, the GenBank accession numbers of each of the sense & antisense ESTs are provided, along with information on which have polyA signals and protein homologies, as determined by the NCBI.

Below are listed the same set of ESTs as is depicted above, with information of read direction, tissue type, protein similarity (P), and poly-adenylation signal (A).

ANTISENSE ESTs
  AI887209 cDNA clone IMAGE:2438127 uterus 3' read Polyadenylation signal
  BG259831 cDNA clone IMAGE:4479954 transitional cell papilloma, cell line 5' read Protein similarity
  AL597726 cDNA clone DKFZp313L0315 5' read
  AL597722 cDNA clone DKFZp313K0315 5' read Protein similarity
  BG577098 cDNA clone IMAGE:4708543 mammary adenocarcinoma, cell line 5' read Protein similarity
  BI094542 cDNA clone IMAGE:4996517 placenta 5' read Protein similarity
  BE790058 cDNA clone IMAGE:3883978 large cell carcinoma 5' read Protein similarity
  R15866 cDNA clone IMAGE:53013 brain 5' read Protein similarity
  BM015422 cDNA clone IMAGE:5417472 mammary adenocarcinoma, cell line 5' read Protein similarity
  AA702535 cDNA clone IMAGE:447109 pool 3' read Protein similarityPolyadenylation signal
  AI022451 cDNA clone IMAGE:1654707 pool 3' read 0.9 kbProtein similarityPolyadenylation signal
  AW029221 cDNA clone IMAGE:2542980 stomach 3' read 0.9 kbProtein similarityPolyadenylation signal
  R15865 cDNA clone IMAGE:53013 brain 3' read Protein similarityPolyadenylation signal
  AI758989 cDNA clone IMAGE:2286911 uterus 3' read 2.5 kbProtein similarity
  BF107433 cDNA clone IMAGE:4043798 placenta 5' read Protein similarity

SENSE ESTs

  F09123 cDNA clone c2xc04 brain 3' read Protein similarity
  BM047554 cDNA clone IMAGE:5457184 carcinoma, cell line 5' read
  AI950935 cDNA clone IMAGE:2548134 four pooled high-grade tumors, including two primary tumors 3' read 1.2 kbProtein similarityPolyadenylation signal
  BE207452 cDNA clone IMAGE:2905554 melanotic melanoma 3' read Protein similarityPolyadenylation signal
  AI985635 cDNA clone IMAGE:2493568 uterus 3' read 2.4 kbProtein similarityPolyadenylation signal
  BE207459 cDNA clone IMAGE:2905583 melanotic melanoma 3' read Protein similarityPolyadenylation signal
  BE207454 cDNA clone IMAGE:2905553 melanotic melanoma 3' read Protein similarityPolyadenylation signal
  BE207455 cDNA clone IMAGE:2905559 melanotic melanoma 3' read Protein similarityPolyadenylation signal
  AA873680 cDNA clone IMAGE:1325787 kidney 3' read Protein similarity
  W47202 cDNA clone IMAGE:324820 3' read 1.8 kbProtein similarityPolyadenylation signal
  AA908289 cDNA clone IMAGE:1441674 breast 3' read 1.7 kbProtein similarityPolyadenylation signal
  BI870525 cDNA clone IMAGE:5404366 adenocarcinoma, cell line 5' read Protein similarity
  BF129294 cDNA clone IMAGE:4054078 primary b-cells from tonsils (cell line) 3' read Protein similarity
  AI560007 cDNA clone IMAGE:2211061 uterus 3' read Protein similarityPolyadenylation signal
  BG775152 cDNA clone IMAGE:4761345 carcinoma, cell line 5' read Protein similarity
  BG775926 cDNA clone IMAGE:4761345 carcinoma, cell line 3' read Protein similarity
  AI973280 cDNA clone IMAGE:2491487 uterus 3' read Protein similarityPolyadenylation signal
  AW149923 cDNA clone IMAGE:2629175 uterus 3' read Polyadenylation signal
  AI923372 cDNA clone IMAGE:2452139 uterus 3' read 0.9 kbProtein similarityPolyadenylation signal
  AW084186 cDNA clone IMAGE:2587548 esophagus 3' read Protein similarityPolyadenylation signal
  AA089469 cDNA clone (no-name) heart 5' read
  AW662683 cDNA clone IMAGE:2974256 colon 3' read
  BG768990 cDNA clone IMAGE:4872509 melanotic melanoma, high mdr (cell line) 5' read Protein similarity
  BE727520 cDNA clone IMAGE:3829962 melanotic melanoma 5' read Protein similarity
  BF981765 cDNA clone IMAGE:4396927 duodenal adenocarcinoma, cell line 5' read Protein similarity
  BE385378 cDNA clone IMAGE:3618218 melanotic melanoma 5' read Protein similarity
  BE302596 cDNA clone IMAGE:2905583 melanotic melanoma 5' read Protein similarity
  BF128636 cDNA clone IMAGE:4054078 primary b-cells from tonsils (cell line) 5' read Protein similarity
  BF035398 cDNA clone IMAGE:3858438 adenocarcinoma 5' read Protein similarity
  BE272687 cDNA clone IMAGE:3347918 renal cell adenocarcinoma 5' read Protein similarity
  BE302592 cDNA clone IMAGE:2905559 melanotic melanoma 5' read Protein similarity
  BE302588 cDNA clone IMAGE:2905554 melanotic melanoma 5' read Protein similarity
  BE390202 cDNA clone IMAGE:3606916 endometrium, adenocarcinoma cell line 5' read Protein similarity
  BG767662 cDNA clone IMAGE:4871600 melanotic melanoma, high mdr (cell line) 5' read Protein similarity
  BE409235 cDNA clone IMAGE:3636234 choriocarcinoma 5' read Protein similarity
  BE741990 cDNA clone IMAGE:3948507 adenocarcinoma cell line 5' read Protein similarity
  BG340879 cDNA clone IMAGE:4575262 primary b-cells from tonsils (cell line) 5' read Protein similarity
  BE742644 cDNA clone IMAGE:3836538 adenocarcinoma cell line 5' read Protein similarity
  BM043339 cDNA clone IMAGE:5432938 carcinoma, cell line 5' read