Computational Discovery of Overlapping Transcriptional Units in the Human & Mouse Genomes

Candidate UniGene cluster:UniGene Cluster Hs.288840
Description:PRO1575 protein
Best-Of-UniGene (BOU) SequenceNM_014092
Genomic Coordiantes Displayed:Bases 5188000 to 5202000 of contig Hs1_4855_24
BOU Orientation Along Contig:LEFT-TO-RIGHT with respect to contig
Link to JPEG of genomic mappingHs.288840.jpeg
Best sense EST/protein match:NM_014092 matched ref|NP_054811.1| (NM_014092) PRO1575 protein [Homo sapiens] (E = 1e-25)
Best antisense EST/protein match:No protein match with an e-value of less than 1e-10

This page provides information on exon-intron structure, mouse-human homologies, polyA signals & locations, and protein homologies of ESTs from directionally-cloned libraries that are members of a UniGene cluster that is a candidate for containing ESTs derived from distinct, overlapping sense & antisense transcripts.
The upper portion of the graph is reserved for the exon-intron mappings of ESTs oriented consistently with the Best-Of-UniGene (BOU) sequence (in gold). The lower portion of the graph is reserved for the exon-intron mappings of ESTs oriented opposite the BOU sequence (in white). Dividing these portions are the exon-intron mapping of the BOU sequence itself (in blue and green). Immedietely below the BOU are HUMMUS-defined streches of sequences highly conserved between mouse and human. The height of each bar is reflective of the % identity of human-mouse homology over a 100 base-pair window centered at a given base. At the left of the graph, the GenBank accession number of the BOU or EST sequence represented along that Y-axis position is listed, along with the UniLib identification number of the library from which that EST was derived.Below the graph, the GenBank accession numbers of each of the sense & antisense ESTs are provided, along with information on which have polyA signals and protein homologies, as determined by the NCBI.

Below are listed the same set of ESTs as is depicted above, with information of read direction, tissue type, protein similarity (P), and poly-adenylation signal (A).

  AA970321 cDNA clone IMAGE:1573015 kidney 3' read 0.4 kbPolyadenylation signal
  AW195266 cDNA clone IMAGE:2699513 myeloid cells, 18 pooled cml cases, bcr/abl rearrangement 3' read Polyadenylation signal
  AA946581 cDNA clone IMAGE:1588592 kidney 3' read 0.7 kbPolyadenylation signal
  BF793327 cDNA clone IMAGE:4347127 adrenal cortex carcinoma, cell line 5' read
  BF687552 cDNA clone IMAGE:4065734 glioblastoma 5' read
  AW440567 cDNA clone IMAGE:2889658 uterus 3' read Polyadenylation signal
  AA096347 cDNA clone (no-name) heart 5' read
  BF666641 cDNA clone IMAGE:4278414 primitive neuroectoderm 5' read
  BF664973 cDNA clone IMAGE:4276667 primitive neuroectoderm 5' read
  BF239503 cDNA clone IMAGE:4134380 from chronic myelogenous leukemia 5' read
  BE546230 cDNA clone IMAGE:3457406 choriocarcinoma 5' read
  BF571030 cDNA clone IMAGE:4243143 melanotic melanoma, high mdr 5' read
  BF971274 cDNA clone IMAGE:4361091 adrenal cortex carcinoma, cell line 5' read
  BF239828 cDNA clone IMAGE:4133064 from chronic myelogenous leukemia 5' read
  BG286213 cDNA clone IMAGE:4500537 transitional cell papilloma, cell line 5' read