Computational Discovery of Overlapping Transcriptional Units in the Human & Mouse Genomes

Candidate UniGene cluster:UniGene Cluster Hs.32978
Description:proprotein convertase subtilisin/kexin type 7
Best-Of-UniGene (BOU) SequenceNM_004716
Genomic Coordiantes Displayed:Bases 2186000 to 2214000 of contig Hs11_9491_24
BOU Orientation Along Contig:RIGHT-TO-LEFT with respect to contig
Link to JPEG of genomic mappingHs.32978.jpeg
Best sense EST/protein match:BF237838 matched ref|XP_052032.2| (XM_052032) similar to proprotein convertase subtilisin/kexin type (E = e-116)
Best antisense EST/protein match:No protein match with an e-value of less than 1e-10


This page provides information on exon-intron structure, mouse-human homologies, polyA signals & locations, and protein homologies of ESTs from directionally-cloned libraries that are members of a UniGene cluster that is a candidate for containing ESTs derived from distinct, overlapping sense & antisense transcripts.
The upper portion of the graph is reserved for the exon-intron mappings of ESTs oriented consistently with the Best-Of-UniGene (BOU) sequence (in gold). The lower portion of the graph is reserved for the exon-intron mappings of ESTs oriented opposite the BOU sequence (in white). Dividing these portions are the exon-intron mapping of the BOU sequence itself (in blue and green). Immedietely below the BOU are HUMMUS-defined streches of sequences highly conserved between mouse and human. The height of each bar is reflective of the % identity of human-mouse homology over a 100 base-pair window centered at a given base. At the left of the graph, the GenBank accession number of the BOU or EST sequence represented along that Y-axis position is listed, along with the UniLib identification number of the library from which that EST was derived.Below the graph, the GenBank accession numbers of each of the sense & antisense ESTs are provided, along with information on which have polyA signals and protein homologies, as determined by the NCBI.

Below are listed the same set of ESTs as is depicted above, with information of read direction, tissue type, protein similarity (P), and poly-adenylation signal (A).

ANTISENSE ESTs
  AA317286 cDNA clone ATCC:117760 eye 5' read Protein similarity
  BF674510 cDNA clone IMAGE:4273702 prostate 5' read Protein similarity
  AW827236 cDNA clone IMAGE:2693784 liver 5' read Protein similarity
  AA373478 cDNA clone ATCC:177865 5' read Protein similarity
  AA373787 cDNA clone ATCC:178162 5' read Protein similarity
  AW105289 cDNA clone IMAGE:2598085 ovary 3' read
  AW173617 cDNA clone IMAGE:2656755 uterus 3' read Protein similarity
  AI085677 cDNA clone IMAGE:1680792 3' read 0.8 kbProtein similarity
  AW028854 cDNA clone IMAGE:2541536 stomach 3' read 2.0 kbProtein similarityPolyadenylation signal
  AW196046 cDNA clone IMAGE:2681655 pancreas 3' read Polyadenylation signal
  AI933602 cDNA clone IMAGE:2448005 stomach 3' read 2.4 kbPolyadenylation signal
  AI926778 cDNA clone IMAGE:2459562 stomach 3' read 1.9 kbProtein similarityPolyadenylation signal
  AW235025 cDNA clone IMAGE:2693784 liver 3' read Protein similarityPolyadenylation signal
  AI073703 cDNA clone IMAGE:1664802 3' read 0.7 kbProtein similarityPolyadenylation signal
  AI081466 cDNA clone IMAGE:1680405 3' read 1.2 kbPolyadenylation signal
  AI086589 cDNA clone IMAGE:1681256 3' read 0.4 kbPolyadenylation signal
  AW068957 cDNA clone HBMSC_cr39b01 bone 3' read Polyadenylation signal
  AI142973 cDNA clone IMAGE:1680660 3' read 1.2 kbPolyadenylation signal
  AI888326 cDNA clone IMAGE:2447106 stomach 3' read Protein similarityPolyadenylation signal
  AI683054 cDNA clone IMAGE:2262967 uterus 3' read 0.6 kbPolyadenylation signal

SENSE ESTs

  BM142544 cDNA clone (no-name) islets of langerhans 3' read Polyadenylation signal
  AI701081 cDNA clone IMAGE:2324781 pancreas 3' read Polyadenylation signal
  BI838907 cDNA clone IMAGE:5226952 pooled pancreas and spleen 5' read Protein similarity
  BG698344 cDNA clone IMAGE:4801520 skin 5' read Protein similarity
  BE046371 cDNA clone IMAGE:3026679 juvenile granulosa tumor 3' read Polyadenylation signal
  AI077301 cDNA clone IMAGE:1673998 pool 3' read 1.0 kbPolyadenylation signal
  AW264941 cDNA clone IMAGE:2759387 two pooled squamous cell carcinomas 3' read Polyadenylation signal
  AI475362 cDNA clone IMAGE:2153575 colon 3' read 1.8 kbPolyadenylation signal
  AA302478 cDNA clone ATCC:114651 aorta 5' read
  AA705310 cDNA clone IMAGE:462837 pool 3' read Polyadenylation signal
  AA367485 cDNA clone ATCC:172266 ear 5' read
  AI367729 cDNA clone IMAGE:1987459 uterus 3' read Polyadenylation signal
  AI538567 cDNA clone IMAGE:2204622 uterus 3' read 3.0 kbPolyadenylation signal
  H09315 cDNA clone IMAGE:45900 brain 3' read 1.8 kbPolyadenylation signal
  AI051182 cDNA clone IMAGE:1673455 pool 3' read 1.1 kbPolyadenylation signal
  W48663 cDNA clone IMAGE:325254 3' read 2.1 kbPolyadenylation signal
  AI955771 cDNA clone IMAGE:2511747 pancreas 3' read 1.3 kbPolyadenylation signal
  BI519855 cDNA clone IMAGE:5211221 leukocyte 3' read
  AA677298 cDNA clone IMAGE:454789 pool 3' read
  AA203530 cDNA clone IMAGE:446543 pool 5' read
  BI490846 cDNA clone IMAGE:5172912 pooled brain, lung, testis 3' read
  BG820292 cDNA clone IMAGE:4932913 anaplastic oligodendroglioma with 1p/19q loss 5' read
  BG033463 cDNA clone IMAGE:4403365 mammary adenocarcinoma, cell line 5' read
  BI193007 cDNA clone IMAGE:5090316 epithelioid carcinoma cell line 5' read
  AA374001 cDNA clone ATCC:178380 5' read
  BI194238 cDNA clone IMAGE:5089252 epithelioid carcinoma cell line 5' read
  AA311512 cDNA clone ATCC:157466 5' read
  BG676856 cDNA clone IMAGE:4748486 squamous cell carcinoma 5' read
  BG424591 cDNA clone IMAGE:4586047 renal cell adenocarcinoma 5' read Protein similarity
  AL045197 cDNA clone DKFZp434E0150 testis 5' read Protein similarity
  BG385345 cDNA clone IMAGE:4582636 adenocarcinoma cell line 5' read Protein similarity
  BG914282 cDNA clone IMAGE:4942709 anaplastic oligodendroglioma with 1p/19q loss 5' read Protein similarity
  BF237985 cDNA clone IMAGE:4080164 leiomyosarcoma cell line 5' read Protein similarity
  BF237838 cDNA clone IMAGE:4080189 leiomyosarcoma cell line 5' read Protein similarity
  BG911103 cDNA clone IMAGE:4939883 anaplastic oligodendroglioma with 1p/19q loss 5' read Protein similarity
  BG769053 cDNA clone IMAGE:4872767 melanotic melanoma, high mdr (cell line) 5' read Protein similarity
  BG760669 cDNA clone IMAGE:4840855 melanotic melanoma, high mdr (cell line) 5' read Protein similarity
  BG764656 cDNA clone IMAGE:4861928 melanotic melanoma, high mdr (cell line) 5' read Protein similarity
  BF794012 cDNA clone IMAGE:4346823 adrenal cortex carcinoma, cell line 5' read Protein similarity
  H09374 cDNA clone IMAGE:45900 brain 5' read 1.8 kbProtein similarity
  BM142371 cDNA clone (no-name) islets of langerhans 5' read
  BI834648 cDNA clone IMAGE:5229249 pooled pancreas and spleen 5' read Protein similarity
  BE870530 cDNA clone IMAGE:3852508 adenocarcinoma 5' read Protein similarity
  W51896 cDNA clone IMAGE:325254 5' read 2.1 kbProtein similarity
  BF968724 cDNA clone IMAGE:4358496 adrenal cortex carcinoma, cell line 5' read Protein similarity
  BG180640 cDNA clone IMAGE:4430546 adenocarcinoma, cell line 5' read Protein similarity
  AA581326 cDNA clone IMAGE:803052 muscle 5' read Protein similarity
  AL602539 cDNA clone DKFZp686D0814 human skeletal muscle 5' read Protein similarity
  BE542659 cDNA clone IMAGE:3453469 placenta 5' read Protein similarity
  BM007347 cDNA clone IMAGE:5440504 spleen 5' read Protein similarity
  BG821680 cDNA clone IMAGE:4867102 adenocarcinoma cell line 5' read Protein similarity
  BG755639 cDNA clone IMAGE:4856318 primary b-cells from tonsils (cell line) 5' read Protein similarity
  BG824118 cDNA clone IMAGE:4878468 adenocarcinoma cell line 5' read Protein similarity
  BI090290 cDNA clone IMAGE:4996698 placenta 5' read Protein similarity
  BI667134 cDNA clone IMAGE:5310678 hypothalamus, cell line 5' read Protein similarity
  BI824343 cDNA clone IMAGE:5181878 pooled brain, lung, testis 5' read Protein similarity
  H58761 cDNA clone HE6WCR40 whole embryo 5' read Protein similarity
  BI195880 cDNA clone IMAGE:4891758 neuroblastoma 5' read Protein similarity
  BI518413 cDNA clone IMAGE:5211221 leukocyte 5' read Protein similarity
  BI910206 cDNA clone IMAGE:5218274 leukocyte 5' read
  BF312998 cDNA clone IMAGE:4125594 neuroblastoma 5' read Protein similarity
  BE779128 cDNA clone IMAGE:3868257 retinoblastoma 5' read Protein similarity
  AU126294 cDNA clone NT2RP1000536 5' read Protein similarity
  AL596942 cDNA clone DKFZp313H0610 5' read Protein similarity
  AU099039 cDNA clone HEP14660 Protein similarity
  BF791381 cDNA clone IMAGE:4343844 adrenal cortex carcinoma, cell line 5' read Protein similarity
  BI559835 cDNA clone IMAGE:5294892 testis, cell line 5' read