Computational Discovery of Overlapping Transcriptional Units in the Human & Mouse Genomes

Candidate UniGene cluster:UniGene Cluster Mm.152812
Description:telomerase associated protein 1
Best-Of-UniGene (BOU) SequenceNM_009351
Genomic Coordiantes Displayed:Bases 6019838 to 6093915 of contig GA_x5J8B7W5WBF
BOU Orientation Along Contig:RIGHT-TO-LEFT with respect to contig
Link to JPEG of genomic mappingMm.152812.jpeg
Best sense EST/protein match:AW319383 matched ref|NP_033377.1| (NM_009351) telomerase associated protein 1 [Mus musculus] (E = e-102)
Best antisense EST/protein match:AA797422 matched dbj|BAB27211.1| (AK010830) data source:SPTR, source key:Q9Y2Z0, (E = 2e-31)


This page provides information on exon-intron structure, mouse-human homologies, polyA signals & locations, and protein homologies of ESTs from directionally-cloned libraries that are members of a UniGene cluster that is a candidate for containing ESTs derived from distinct, overlapping sense & antisense transcripts.
The upper portion of the graph is reserved for the exon-intron mappings of ESTs oriented consistently with the Best-Of-UniGene (BOU) sequence (in gold). The lower portion of the graph is reserved for the exon-intron mappings of ESTs oriented opposite the BOU sequence (in white). Dividing these portions are the exon-intron mapping of the BOU sequence itself (in blue and green). Immedietely below the BOU are HUMMUS-defined streches of sequences highly conserved between mouse and human. The height of each bar is reflective of the % identity of human-mouse homology over a 100 base-pair window centered at a given base. At the left of the graph, the GenBank accession number of the BOU or EST sequence represented along that Y-axis position is listed, along with the UniLib identification number of the library from which that EST was derived.Below the graph, the GenBank accession numbers of each of the sense & antisense ESTs are provided, along with information on which have polyA signals and protein homologies, as determined by the NCBI.

Below are listed the same set of ESTs as is depicted above, with information of read direction, tissue type, protein similarity (P), and poly-adenylation signal (A).

ANTISENSE ESTs
  BG294702 cDNA clone IMAGE:4504168 retina 5' read
  BG294847 cDNA clone IMAGE:4503784 retina 5' read Protein similarity
  AA672094 cDNA clone IMAGE:963887 mammary gland 5' read
  AA048299 cDNA clone IMAGE:477386 embryo 5' read
  AA616123 cDNA clone IMAGE:1066960 mammary gland 5' read
  W87045 cDNA clone IMAGE:407351 embryo 5' read
  AA797422 cDNA clone IMAGE:1244886 mammary gland 5' read Protein similarity
  AA048431 cDNA clone IMAGE:477513 embryo 5' read
  BI991302 cDNA clone (no-name) neural retina
  BI734946 cDNA clone IMAGE:5363508 retina 5' read

SENSE ESTs

  BF585027 cDNA clone IMAGE:4218678 colon 5' read Protein similarity
  AA929429 cDNA clone IMAGE:699719 pool 5' read Protein similarity
  BE570119 cDNA clone IMAGE:3709525 infiltrating ductal carcinoma 5' read Protein similarity
  BE225659 cDNA clone (no-name) pancreatic bud 3' read Protein similarity
  BG075056 cDNA clone H3142G05 3' read Protein similarity
  AA832806 cDNA clone IMAGE:1433067 uterus 5' read Protein similarity
  BG866828 cDNA clone IMAGE:4912718 salivary gland 5' read Protein similarity
  AA789995 cDNA clone IMAGE:1177434 colon 5' read Protein similarity
  BE226140 cDNA clone (no-name) pancreatic bud 5' read Protein similarity
  AI643862 cDNA clone IMAGE:1195798 mammary gland 3' read
  BF120380 cDNA clone IMAGE:3985735 tumor, gross tissue 5' read Protein similarity
  BI662163 cDNA clone IMAGE:5350628 tumor, gross tissue 5' read Protein similarity
  AV288474 cDNA clone 5033411F15 ovary and uterus Protein similarity
  AA542372 cDNA clone IMAGE:933536 embryo 5' read Protein similarity
  AW321306 cDNA clone IMAGE:2616345 infiltrating ductal carcinoma 5' read Protein similarity
  BB564578 cDNA clone 2010014O07 small intestine 5' read Protein similarity
  BE570682 cDNA clone IMAGE:3603052 infiltrating ductal carcinoma 5' read Protein similarity
  BG972761 cDNA clone IMAGE:4972207 kidney 5' read Protein similarity
  AW740915 cDNA clone IMAGE:2803406 thymus 5' read Protein similarity
  BF385033 cDNA clone IMAGE:4195374 liver 5' read Protein similarity
  BI986890 cDNA clone (no-name) neural retina
  AW319383 cDNA clone IMAGE:2395432 kidney 5' read Protein similarity