I am now an assistant professor at the Department of Biological Sciences at Columbia University in the City of New York .
My homepage has moved!
Previously, I was a fellow at the
Church Lab in the
Department of Genetics ,
Harvard Medical School .
I finished my PhD in the
School of Computers Science and Engineering,
Hebrew University of Jerusalem
working with Prof. Nir Friedman.
My research focuses on understanding the design and function of molecular networks.
With the advent of high throughput genomic and proteomic technologies, biology is experiencing an
explosion of new experimental results. A major challenge is to use this data to reveal a
coherent systems level view of the cell. My objective is to use computational learning techniques
to understand the architecture of molecular networks and elucidate a global view of how the molecular
network processes combinations of signals to compute and execute a concerted cellular decision and response.
My approach uses Bayesian network inference algorithms to reconstruct models of molecular networks
by integrating diverse high throughput data. These models are then used to generate predictions
of the systems behavior underd different conditions and illuminates the roles of various
components causing these behaviors. Recently the approach was successfully applied to the
derivation of causal influences in human signaling networks.
The method automatically discovered de novo, most traditionally
established influences between the measured signaling components, as well as discovering novel
inter-pathway crosstalk, which was experimentally verified.