Causative SNPs can be in non-coding repeats

aggcAggtggatca

aggcGggtggatca

ALU repeat found upstream of Myeloperoxidase

“severalfold less transcriptional activity”

"-463 G creates a stronger SP1 binding site &

retinoic acid response element (RARE) in the allele...

overrepresented in acute promyelocytic leukemia"

Piedrafita FJ, et al. 1996 JBC 271: 14412

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