Common Disease – Common Variant Theory. How common?

ApoE allele e4 : Alzheimer’s dementia,

& hypercholesterolemia

20% in humans, ᢙ% in chimps

HbS 17% & G6PD 40% in a Saudi sample

CCR5D32 : resistance to HIV

9% in caucasians

Previous slide

Next slide

Back to first slide

View graphic version