How many "new" polymorphisms?

G= generations of exponential population growth = 5000

N'= population size = 6 x 109 now; N= 104 pre-G

m= mutation rate per bp per generation = 10-8 to 10-9 (ref)

L= diploid genome = 6 x 109 bp

ekG = N'/N; so k= 0.0028

Av # new mutations < S Lektm = 4 x 103 to 4 x 104

per genome t=1 to 5000

Take home: "High genomic deleterious mutation rates in hominids"

accumulate over 5000 generations & confound linkage methods

And common (causative) allele assumptions.

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