Use of DNA Chips for SNP ID & Scoring

Wang et al., Science 280 (1998): 1077

• Used for mutation detection with HIV-1, BRCA1, mitochondria

• higher throughput and potential for automation

• ID of > 2000 SNPs in 2 Mb of human DNA

• Multiplex reactions 50-fold

T

G

C

A

T

TTGAACA G

(Context) C

A

T

TTGCACA G

C

A

A/A A/C C/C

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