Functional category enrichment odds

N genes total; s1 = # genes in a cluster; s2= # genes in a particular functional category (“success”); p = s2/N; N=s1+s2-x

Which odds of exactly x in that category in s1 trials?

Binomial: sampling with replacement.

or Hypergeometric: sampling without replacement:

Odds of getting exactly x = intersection of sets s1 & s2:

ref

(Wrong!)

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