Avoiding receptor cross-talk

Ligands: steroids, retinoids, vitaminD, thyroid hormone

Transduction specificity: Steroid response elements

AGGTCA Nn AGGTCA

Half site: AGGTCA or rGkTCr or TAAGGTCA (GR: AGAACA)

DR3 VDR Vitamin D3

DR2,IR0 RAR 9-cis-retinoate

DR5,DR15 RXR trans-Retinoate

DR4 T3R thyroid

IR3,DR15 ER estrogen

Targeting one member of a protein family

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