Bio 101: Genomics & Computational Biology

11/27/01


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Table of Contents

Bio 101: Genomics & Computational Biology

Net2: Last week's take home lessons

Net3: Today's story & goals Bio101 5-Dec-2000

Faster than exponential

The human neural net

Olfactory integration: glomeruli

Basic olfactory tasks

Odor space and olfactory processing: Collective algorithms & neural implementation

Olfaction code

Systems biology model sharing

Net3: Today's story & goals Bio101 5-Dec-2000

Design and strategy for the Cardiome Project

Modeling SNP to 3D to cell morphology & pathology

Red Blood Cell Function

3D-structure to function to morphology to function

From SNPs to pathogen resistance mechanisms

From SNPs to toxicology mechanisms

PPT Slide

A possible molecular mechanism governing human erythrocyte shape.

Red cell distortion and conceptual basis of diffusing capacity estimates: finite element analysis

Action Potential Model for Canine Ventricular Cell

Canine Ventricular Simulations

Whole body recirculation model with four chambered heart, seven organs, four arteries and four veins

Net3: Today's story & goals Bio101 5-Dec-2000

The Sims:

Integration of multiple inputs: Think globally; act locally:

Think globally; act locally

Facts of Life 101

HIV-1 resequencing

Resistance to HIV-1: allele association

HIV-1 resistance to reverse transcriptase targeted drugs

Vaccines for the 21st Century

Growth & decay

HIV-AIDS models

HIV treatement model parameters

Crossing the Hopf bifurcation in a live predator-prey system.

Predator -- prey

Human microbial ecology: Sorting out cause, effect & prescription (vaccine paradox)

Net3: Today's story & goals Bio101 5-Dec-2000

Human Genome Project Ethical, Legal & Social Issues (ELSI)

Human Genome Project Ethical, Legal & Social Issues (ELSI)

ELSI: Do Races Differ? Not Really, DNA Shows

a-ab-an-anti-de-dis-in-neg-non-pseudo-un-scientific

Biowarfare

Genetically modified organisms (GMO)

Genetically modified organisms

Cloning & stem cells

Net3: Today's story & goals Bio101 5-Dec-2000

Models for education & decision-making

Measures of quality of structural & functional genomic data

Compu-bio-physico-physio- eco-econo-aesthetico- edu-journalismetrics

Systems biology model sharing

101 after '01

Multi-thanks to

Teaching Fellows 2001

Author: George M. Church

Home Page: http://www.courses.fas.harvard.edu/~bphys101/