Design and strategy for the Cardiome Project
Adv Exp Med Biol 1997;430:325-39 Bassingthwaighte JB
The Physiome Project has the goal of providing the quantitative description of the integrated functions of the living organism ... a central scheme, a description of the spread of excitation and contraction through an anatomically detailed cardiac model with fiber directions. This will be augmented by the additions of regional blood flows, substrate uptake and metabolism, and energy production and utilization in serving contraction and ionic balances. Later stages will involve cellular regulation and responses to interventions. The organization of such projects is by the assembling of components whose linkages one to another are first minimized and then augmented to improve the approximation to reality.