Vaccines for the 21st Century
Level I Most favorable: saves money & Quality-Adjusted Life Years(QALY)
Level II < $10,000 < Level III < $100K per QALY saved < Level IV
Level I candidate vaccines:
Viral: CMV vaccine for 12 year olds, Flu vaccine for 20% of the US per year.
Therapeutic vaccines: IDDM diabetes, MS, Rheumatoid arthritis
• Bacterial: Streptococcus B & pneumoniae vaccine for infants & 65 year olds.
[HIV vaccines prominent already within NIH.]
“A quantitative model that could be used by decision makers to prioritize the development of vaccines against a number of disparate diseases” 1985 & 1999.