HIV-AIDS models
Resistance, Remission, & Qualitative Differences in HIV Chemotherapy (Pub)
Therapy T(0),Vs(0) in mm-3 =
The rates of exponential increase in Fig. 2a (.03, .02, .01, .005) are inversely correlated to starting CD4+ T-cell counts; decay rates in Fig 2b (all -.2) are not correlated to starting viral levels (different viral set-points would give different values for the parallel slopes) (1,2). The lack of correlation of viral decay rates is an indication of slower clearance of wild-type virus in the external lymphoid compartment. The time to the downward spike in Figure 2b is correlated to starting viral levels (1). The treatment parameters c1=2.0, c2=.17, c3=.15 and the resistance mutation parameter q=10-6 are the same in all four simulations.