Increasingly complex (accurate) searches
Exact (StringSearch) CGCG
Regular expression (PrositeSearch) CGN{0-9}CG = CGAACG
Substitution matrix (BlastN) CGCG ~= CACG
Profile matrix (PSI-blast) CGc(g/a) ~ = CACG
Gaps (Gap-Blast) CGCG ~= CGAACG
Dynamic Programming (NW, SM) CGCG ~= CAGACG