Utilizing Noise
Hasty, et al. PNAS 2000; 97:2075-2080, Noise-based switches and amplifiers for gene expression (Pub)
“Bistability ... arises naturally... Additive external noise [allows] construction of a protein switch... using short noise pulses. In the multiplicative case, ... small deviations in the transcription rate can lead to large fluctuations in the production of protein”.
Paulsson, et al. PNAS 2000; 97:7148-53. Stochastic focusing: fluctuation-enhanced sensitivity of intracellular regulation. (Pub) (exact master equations)