Stochastic models for CNC
Paulsson & Ehrenberg, J Mol Biol 1998;279:73-88. Trade-off between segregational stability and metabolic burden: a mathematical model of plasmid ColE1 replication control. (Pub),
J Mol Biol 2000;297:179-92. Molecular clocks reduce plasmid loss rates: the R1 case. (Pub)
While copy number control for ColE1 efficiently corrects for fluctuations that have already occurred, R1 copy number control prevents their emergence in cells that by chance start their cycle with only one plasmid copy. Regular, clock-like, behaviour of single plasmid copies becomes hidden in experiments probing collective properties of a population of plasmid copies ... The model is formulated using master equations, taking a stochastic approach to regulation”