Factors Constraining Metabolic Function

• Physicochemical factors:

  • Mass, energy, and redox balance:
    • Systemic stoichiometry
  • osmotic pressure, electroneutrality, solvent capacity, molecular diffusion, thermodynamics
  • Non-adjustable constraints

• System specific factors:

  • Capacity:
    • Maximum fluxes
  • Rates:
    • Enzyme kinetics
  • Gene Regulation
  • Adjustable constraints

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