Biophysics 101 Genomics and Computational Biology

2/15/01


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Table of Contents

Biophysics 101 Genomics and Computational Biology

Net2: Last week's take home lessons

Net3: Today's story & goals Bio101 5-Dec-2000

Integration of multiple inputs: Think globally; act locally:

The Sims

Systems biology model sharing

Signaling PAthway Database SPAD

Net3: Today's story & goals Bio101 5-Dec-2000

Olfactory integration: glomeruli

1) Odor memory and recognition. 2) Background elimination (one known + unknown thoroughly mixed) 3) Component separation. (few known odors mixed) 4) Odor separation (turbulent unknowns)

Odor space and olfactory processing: Collective algorithms & neural implementation

Net3: Today's story & goals Bio101 5-Dec-2000

Design and strategy for the Cardiome Project

Modeling SNP to 3D to cell morphology & pathology

Red cell distortion and conceptual basis of diffusing capacity estimates: finite element analysis

Action Potential Model for Canine Ventricular Cell

Canine Ventricular Simulations

Whole body recirculation model with four chambered heart, seven organs, four arteries and four veins

Net3: Today's story & goals Bio101 5-Dec-2000

Facts of Life 101

HIV-1 resequencing

One form of HIV-1 Resistance

An association test for CCR-5 & HIV resistance

Covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance

Vaccines for the 21st Century

Rorschach Test

Growth & decay

HIV-AIDS models

HIV treatement model parameters

Crossing the Hopf bifurcation in a live predator-prey system.

Predator -- prey

Human microbial ecology: Sorting out cause, effect & prescription (vaccine paradox)

Think globally; act locally

Net3: Today's story & goals Bio101 5-Dec-2000

Human Genome Project Ethical, Legal & Social Issues (ELSI)

Human Genome Project Ethical, Legal & Social Issues (ELSI)

ELSI: Do Races Differ? Not Really, DNA Shows

a-ab-an-anti-de-dis-in-neg-non-pseudo-un-scientific

Biowarfare

Genetically modified organisms (GMO)

GMO

Net3: Today's story & goals Bio101 5-Dec-2000

Models for education & decision-making

Measures of quality of structural & functional genomic data

Compu-bio-physico-physio- eco-econo-aesthetico- edu-journalismetrics

Systems biology model sharing

101 in '01

Multi-thanks to

Teaching Fellows 2000

Committee on Undergraduate Education (CUE) & Division of Continuing Education (DCE) Evaluations

Biophysics 101 Genomics and Computational Biology

Author: George M. Church

Home Page: arep.med.harvard.edu