Vaccines for the 21st Century
Level I Most favorable: saves money & Quality-Adjusted Life Years(QALY)
Level II Costs < $10,000 per QALY saved
Level III Costs > $10,000 and <$100,000 per QALY saved
Level IV Costs >$100,000 per QALY saved
The Level I candidate vaccines:
• cytomegalovirus (CMV) vaccine administered to 12 year olds,
• influenza virus vaccine administered to one-fifth of the population per year.
• insulin-dependent diabetes mellitus therapeutic vaccine,
• multiple sclerosis therapeutic vaccine,
• rheumatoid arthritis therapeutic vaccine,
• Group B streptococcus vaccine for routine prenatal care, women during first pregnancy and high-risk adults,
• Streptococcus pneumoniae vaccine to be given to infants and to 65 year olds.
[HIV vaccines not within the scope project, prominent already within NIH.]