Expression Data Set 64 details

Information Item Value
Dataset Name Yeast Genome Expression Responses to Environmental Changes
Dataset Number 64
Short Description Expression Time Series following treatment with heat, acid, alkali, hydrogen peroxide, salt,
sorbital, and during diauxic shift
Source URL
Reference Causton, HC; Ren, B; Koh, SS; Harbison, CT; Kanin E; Jennings, EG; Lee, TI; True, HL; Lander, ES;
Young, RA; Remodeling of Yeast Genome Expression in Response to Environmental Changes.; Mol Biol Cell
12:323-337 (2001)
Strains S288C strain ATCC-201388
Conditions Grown on YPD
Date Added to ExpressDB Sep 5 2002 11:41:41:353AM
Number of Measures on ExpressDB 90 (here to download dataset and view measure details)
Long Description Abstract from reference: We used genome-wide expression
analysis to explore how gene expression in Saccharomyces cerevisiae is
remodeled in response to various changes in extracellular environment,
including changes in temperature, oxidation, nutrients, pH, and
osmolarity. The results demonstrate that more than half of the genome
is involved in various responses to environmental change and identify
the global set of genes induced and repressed by each condition. These
data implicate a substantial number of previously uncharacterized
genes in these responses and reveal a signature common to
environmental responses that involves ~10% of yeast genes. The results
of expression analysis with MSN2/MSN4 mutants support the model that
the Msn2/Msn4 activators induce the common response to environmental
change. These results provide a global description of the
transcriptional response to environmental change and extend our
understanding of the role of activators in effecting this response.

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Copyright (c) 2006 by Wayne Rindone and the President and Fellows of Harvard University