NIH Center of Excellence in Genomic Science (CEGS)
Molecular and Genomic Imaging Center (MGIC)
This Center will focus on new technologies to make "personal genomics" affordable. Genome and transcriptome resequencing will be applied to cancer and stem cell RNA measurements. The core technology is based on single-molecule polymerase colonies (nicknamed "polonies") and fluorescent base extension.
A strong emphasis will be on collaborations and transfer of the technology to commercial and clinical settings.
See: Nature Reviews of Genetics paper , Polony technology updates, Personal Genomics (PGP).
Minority Training Opportunities
MGIC Collaborating groups:
Rob Mitra, Washington Univ., St. Louis; lab;
George Church, Harvard & MIT; lab.
James Sherley, MIT lab
David Gottlieb, Washington Univ., St. Louis.; lab.
27-Nov-01 Program announcement.
1-Jun-02 First Proposal
26-May-03 Second Proposal CD & paper copies complete.
1-Jun-03 Full CEGS Proposal (with hypertext links to local "CD-ROM" files)
16-Sep-03 Update. 1 P50 HG003170-01
11-Nov-03 Reviewers questions and our answers.
23-Dec-03 Final Reviewer's comments (and cover letter).
20-Jan-04 Informal update.
10-Feb-04 National Advisory Council for Human Genome Research meeting.
10-Mar-04 Final decision. 1-Aug-2004 Start.
NHRGI Sequencing Technology Development grantees 2004 & 2005 & 2006.
Full list of NHGRI's CEGS Centers:
2002-2007 Jingyue Ju, Columbia University, New York; Genomic Approaches to Neuronal Diversity and Plasticity
2002-2007 Maynard V. Olson, University of Washington, Seattle; Study of Natural Genetic Variation.
2003-present Roger Brent, Molecular Sciences Institute, Berkeley, Genomic Experimentation and Computation.
2002-present Deirdre Meldrum, Seattle then Arizona State Univ.; Integrated Biologically-Active Microsystems then Microscale Life Sciences Center (also Seattle, Brandeis)
2002-present Michael Snyder, Yale University, New Haven;
Analysis of Human Genome Using Integrated Technologies
2003-present William Talbot then David Kingsley, Stanford University School of Medicine, Palo Alto; Genomic Basis of Vertebrate Diversity
2003-present Michael Waterman, University of Southern California, Los Angeles; Implications of Haplotype Structure in the Human Genome
2004-present George Church, Harvard/MIT, Boston; Molecular & Genomic Imaging Center.
2004-present Andrew Feinberg, Johns Hopkins, Baltimore; Epigenetics of Common Human Disease
2007-present Marianne Bronner-Fraser, Caltech, Pasadena; Center for In Toto Genomic Analysis of Vertebrate Development (see also Megason at HMS; Fraser at JHU)
2007-present Marc Vidal, DFCI/HMS, Boston; Center for Cancer Systems Biology