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The work of this group focuses on interaction between proteins and between protein and DNA. Examples of such studies are the mechanisms by which the DNA topoisomerases manipulate DNA strands; the architecture of ternary complexes of DNA; DNA topoisomerases and anticancer drugs; the nature of genetically silent loci in Escherichia coli and yeast; the interplay between transcription and supercoiling of intracellular DNA; the chemical and photochemical probing of protein and protein-nucleic acid interfaces; and the effect of intracellular DNA structure on genome stability.
Berger, J. M., Gamblin, S. J., Harrison, S. C., and Wang, J. C., Structure at 2.7 A resolution of a 92K yeast DNA topoisomerase II fragment, Nature, 379, 225 -232 (1996).
Roca, J., and Wang, J.C., The probabilities of supercoil removal and decatenation by yeast DNA topoisomerase II, Genes to Cells 1, 17 -27 (1996).
Hanai, R., Caron, P. R., and Wang, J. C., Human TOP3: A single-copy gene encoding DNA topoisomerase III. Proc. Natl. Acad. Sci. USA 93, 3653 -3657 (1996).