Negative Controls

• 250 AlignACE runs on 50 groups each of 20, 40, 60, 80,and 100 orfs, resulting in 3692 motifs.

• Allows calibration of an expected false positive rate for a set of hypotheses resulting from any chosen cutoffs.

MAP > 10.0

Spec. < 1e-5

Example:

Functional Categories

Random Runs

82 motifs (24 known)

41 motifs

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