%PDF-1.6
%
168 0 obj
<><><>]/ON[244 0 R]/Order[]/RBGroups[]>>/OCGs[244 0 R]>>/Outlines 82 0 R/PageLabels 159 0 R/Pages 161 0 R/Type/Catalog/ViewerPreferences<>>>
endobj
169 0 obj
<>/Font<>>>/Fields[]>>
endobj
165 0 obj
<>stream
application/pdf
doi:10.1038/nbt.1590
Peter A Carr
George M Church
Nature Biotechnology 27, 1151 (2009). doi:10.1038/nbt.1590
Nature Publishing Group
© 2009 Nature Publishing Group
Genome engineering
Adobe PDF Library 8.0
© 2009 Nature Publishing Group
10.1038/nbt.1590
1546-1696
1162
1087-0156
12
Nature Biotechnology
permissions@nature.com
1151
27
2009-12-01
http://dx.doi.org/10.1038/nbt.1590
2009-11-23T16:46:30+05:30
Adobe InDesign CS3 (5.0.4)
Nature Biotechnology 27, 1151 (2009). doi:10.1038/nbt.1590
2009-12-02T11:56:30-05:00
2009-12-02T11:56:30-05:00
doi:10.1038/nbt.1590
True
uuid:3b930486-ad70-4786-ab2f-baa302f8018b
uuid:560e5b47-cb3b-4bf6-8933-f5c756950f84
endstream
endobj
170 0 obj
<>
endobj
82 0 obj
<>
endobj
159 0 obj
<>
endobj
161 0 obj
<>
endobj
162 0 obj
<>
endobj
163 0 obj
<>
endobj
26 0 obj
<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/Rotate 0/TrimBox[0.0 0.0 594.0 783.0]/Type/Page>>
endobj
28 0 obj
<>/Font<>/ProcSet[/PDF/Text]/Properties<>/MC1<>/MC2<>/MC3<>>>/XObject<>>>/Rotate 0/TrimBox[0.0 0.0 594.0 783.0]/Type/Page>>
endobj
34 0 obj
<>/Font<>/ProcSet[/PDF/Text/ImageC]/Properties<>>>/XObject<>>>/Rotate 0/TrimBox[0.0 0.0 594.0 783.0]/Type/Page>>
endobj
38 0 obj
<>/Font<>/ProcSet[/PDF/Text]/Properties<>>>/XObject<>>>/Rotate 0/TrimBox[0.0 0.0 594.0 783.0]/Type/Page>>
endobj
41 0 obj
<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/Rotate 0/TrimBox[0.0 0.0 594.0 783.0]/Type/Page>>
endobj
46 0 obj
<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/Rotate 0/TrimBox[0.0 0.0 594.0 783.0]/Type/Page>>
endobj
59 0 obj
<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/Rotate 0/TrimBox[0.0 0.0 594.0 783.0]/Type/Page>>
endobj
269 0 obj
<>stream
HێۺݯS kF$u=88&uIQȲ֫FIDKp8!sK7#˵>=qZ̏cf'u#$|nҏ0"5 ʳ%R]J5Ty%#e2B
-ơ̦4`?gvIiyb}i-ӟ~@H-{PD"GE'灮ז|+)( 0ۉq w}kMQͻ-ySV 㑰c*F/;ucD@5$[fܫv Bos't[an_a|}f]yOTr<^4Oci ğӈA̭r?-geeU! jey*)VBEEWL~Et|\)
O{ZgY9fCvhܥ%+Jlm9 5#T}T5K =@Chݮ |몔E s!~opGRr,?2,e#!d"Y֙@lP/A1c`PAu=%~#(bl ,fSZ^HgЏzr$襱h?}!
;D kƀ'hgCu!5ԍ
mX,10fk\k9h擐G+f^1uR H"U'ݷ &i7NW!!OȧC:M7d)j
B0h)a$wY)Y8jJdSGG<05V;HD pgw|g-sэ&rJy3̉ĞEV~jmq_ b\bqαRܿ(b.0wpgW×UVm3|{S7h_j2&W_DQ:[
sb8ڜSI|O#e
~?2j>\~9]<¼h"Գ|xEeGȸ80'.gkW?J@H~p~ZIDQhmPP ^(q-ĠK[[.y &A
ڐ
|>g`(JĦ*iUm0gxF46}=S=,JuQ~CAwbRv#v$tX6Ou۬9M T6;RqtB]9 ]Uv*58bQV$??PIqf2U{P^lK.-
YzMcdBW
»FU5huYkƝJ;5Qq*?
V#AѪQZ5E#xTڬ_^8
ի7tKywRWu*UM
}m4>ZĦjW}@ݤ7P^na[He/ǏA2XàSCԈKL*)ja$۽Ht'ճ,gђb]I/8z$ߓ?Vc3@"|yw\hd_SU^Ao o9xأhG32@o%}*^W;"ʿA[CS[w36,|;BWn*:RCI}z1L'kZj5)Nj YI1m`fiQ.ew]ě~EqQIgQ%@d,l;u2̈]Sw(`7{f gO+vUq.
qhp { @bߴ7Q(]࢛-$6O\">6PO"M]:q$c'R.v8=(#3*3Dz?ӏȜk_ooJ
U]$"ΝbOCהac@*G4(4p9-Xu?v$S
rϏ}J Wr$}kMGIJmP'bP+aFCfs}[z}G+˧6ӭ
UٜX(`?һWUSXrxALuYt'FT؛h¾9y1Щk}}hv0|J#O;xp=8Kym-(zU{l?8++2Z/_&^L:&}]m.dX_DOo*YlT6mJ'*3UǞaWLjذfΨxV"<97OntE~#"R8e6k$eA^>lU6\IT [wNQzw]0
3ZeT?fmJ:)Qg-h{PkA_4_0͝aMhYWZDZR0d]/7L!qFOEgں6r_ɓ'd4٤&O45xL*/M__3o|!gp0oE@rx#h>')a
E#7((7kn\`#θ2g%CddIç=r}3gOe4r"~d l>(\`8a҅{v}LT͏$v몮E%+Q꺪gT>d}]A
WYU6l:mv[ٙV7R [$֨T߷T7:>tnm};ǃLĹfgLv\eU| ;lAh}#k0Zeռ}B#Ҵ5Xl֥!_cbӉz
q!'fӧ#:t3,Y0Ԉ쵻|rv妫%ZE `)A9OJ wUEU@i_(*uL[2&Z˪QG/kTfWۮ?jtnHKryÈ0k~g2e>-%az>)3؈VɥU6?
ʴ@ҎH39[!Uv
遭7L~|=To
fMIfl`u#[9}{|KS.<>"e@d~9b/b'^
%f0Y3܊/߁CiAZ!-F
y_!`{lw.Y\-Ҕylağ:?yvxE0Ǫ//Sj芝Ad͘<՜ l&f(P_92ɩ+Ux؈i;8xUfBqWYQ]+揻ۡrq t!~;2g%b!y
˞.6 ^.N~P\wz^ٿcRLɉ_)31aR#W]Ѧp
˴iPiVKXrBtf-Y{R"\o˘4|x@SabVM&mΗxe#$$%yeLZn>X Tph6{V++xa?$'$Sj7{GsQY?f5%v~\G-aK+7,Gsiٱ?XzK!c=fTM ^kt <v?kG A@&(^w:R~3z<53IH. ]Q^!AK˟J:bK6 R%snr^TJŠG%kO
;y
+Jj(JCaHʹ֬ɹ#J%*Rj,=_`NWFw%=a^` b]&GJ40B{"yVELűοgz[ C>[ ழlUSi+6NA(+6Jߢn}
js"hn@m v&Cה\#小 !>09N
jV}[oD:&R!= M'^-^%?vPd#."ƶ(wIa}J^h(2C~eJ[,&h