Given many genome sequences (of accuracy 99.99%)

Sequence to exon 80% [Laub 98]

Exons to gene (without cDNA or homolog) ~30% [Laub 98]

Gene to regulation ~10% [Hughes 00]

Regulated gene to protein sequence 98% [Gesteland ]

Sequence to secondary-structure (a,b,c) 77% [CASP]

Secondary-structure to 3D structure 25% [CASP]

3D structure to ligand specificity ~10% [Johnson 99]

Expected accuracy overall ~ = 0.8*.3*.1*.98*.77*.25*.1 = .0005 ?

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