Structural genomics projects
1) Assign function to proteins with only cellular or phenotypic function
2) Assign functional differences within a sequence family
3) Interpret disease associated single nucleotide polymorphisms (SNPs).
Selection criteria 35% identity clusters:
Large Families with a predefined limit on sequence length
Families in all 3 main domains of life (prokaryotes, archaea, eukaryotes)
Families with a human member
Families without a member of known structure
Non-transmembrane families
Current estimated cost: $200K/structure
Target cost: 10,000 per 5 years = $8K/structure.