A sticker-based model for DNA computation.
Roweis et al. J Comput Biol 1998; 5:615-29 (Pub, JCB)
Unlike previous models, the stickers model has a random access memory that requires no strand extension and uses no enzymes.
In theory, ...reusable. [We] propose a specific machine architecture for implementing the stickers model as a microprocessor-controlled parallel robotic workstation…
Concerns about molecular computation (Smith, 1996; Hartmanis, 1995; Linial et al., 1995) are addressed:
1) General-purpose algorithms can be implemented by DNA-based computers
2) Only modest volumes of DNA suffice.
3) [Altering] covalent bonds is not intrinsic to DNA-based computation.
4) Means to reduce errors in the separation operation are addressed in
Karp et al., 1995; Roweis and Winfree, 1999).