A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations

Raamsdonk et al. 2001 Nature Biotech 19:45.

-40C MeOH> 80C EtOH > Cobas Enzymatic BioAutoanalyser

& Quantitative 1H NMR 0 to 4.4 ppm (1300 measures)

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